IndraLab

Statements

USP37 activates epithelial to mesenchymal transition. 20 / 20
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"USP37 is a modulator of the epithelial-mesenchymal transition and metastasis ."
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"In contrast, USP37 upregulation promotes EMT, migration, and invasion [39]."
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"Therefore, USP37 promotes EMT via the SHH pathway, and the signalling outcomes are determined by the balance of activated and inhibitory GLI1 proteins [39]."
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"Snail protein is an essential positive regulator of EMT, which is upregulated by USP37."
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"Thus, the literature survey and also TCGA database analyses signify that USP37 is upregulated in different types of cancers and the role of USP37 in modifying the EMT by stabilizing the EMT modifier SNAIL has been reported."
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"USP37 also participates in the sonic hedgehog (SHH) pathway and the stability of GLI1 protein and promotes EMT."
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"Initial studies have shown that in other cancers USP37 directly regulates the stability of EMT regulating proteins like SNAIL."
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"The knockdown of USP37 could inhibit the stemness , cell invasion and EMT via downregulation of Hedgehog pathway ."
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"USP37 up-regulation promoted the proliferation, cell cycle progression, apoptosis inhibition, migration, invasion, epithelial mesenchymal transition (EMT) and stemness of CRC cells; moreover, USP37 facilitated the angiogenesis of human umbilical vein endothelial cells (HUVECs)."
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"USP37 in breast cancer was reported to increase cell stemness, epithelial‐mesenchymal transition (EMT), and invasion, while to decrease the sensitivity to cisplatin."
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"On the contrary, upregulation of USP37 promoted EMT, migration and invasion."
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"Therefore , USP37 promotes EMT via the SHH pathway , and the signalling outcomes are determined by the balance of activated and inhibitory GLI1 proteins [ 39 ] ."
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"USP34 and USP37 stimulate EMT in mammary epithelial cells [84,85] ."
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"Further studies indicated that USP37 knockdown could inhibit the stemness, cell invasion and EMT in breast cancer via downregulation of Hh pathway."
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"The knockdown of USP37 could inhibit the stemness, cell invasion and EMT via downregulation of Hedgehog pathway."
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"USP37 knockdown inhibits stemness , cell invasion and EMT via Hedgehog signaling pathway in breast cancer ."
| PMC
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"USP37 knockdown inhibits stemness , cell invasion and EMT via Hedgehog signaling pathway in breast cancer ."
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"In order to understand the mechanism of USP37-induced EMT and stemness via the Hh pathway, we treated MCF-7 cells with PM."
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"These data confirm that USP37 mediates breast cancer stem-like properties , cell invasion and EMT via the Hh pathway ."
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"Knockdown of USP37 expression hampered cell invasion , stemness , EMT and also resulted in the drug sensitivity to cisplatin ."
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