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USP25 increases the amount of RELA. 3 / 3
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"Here, we show that USP21 mediated deubiquitination of IL-33 affects the transcription of p65."
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"Additionally, p65 protein expression levels were increased in bladder cancer cells by USP21 in a dose-dependent manner (Fig. 7J)."
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"Their results demonstrated that USP21 promotes the transcription of p65 via deubiquitylation and stabilization of IL-33, which functions as a transcriptional regulator of p65 and induces the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through its regulatory effect on the NF-κB pathway in endothelial cells (Choi et al., 2012; Tao et al., 2014)."
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