IndraLab

Statements

BECN1 activates USP10. 4 / 4
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"USP10 is a de-ubiquitinating enzyme that promotes accumulation of p53, so Beclin1 mediates down-regulation of USP10 and reduces p53 levels [XREF_BIBR]."
24710490
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"Taken together, these results suggest that Beclin1 is the primary target of USP10 and USP13."
21962518
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"Another interesting observation made in the Spautin-1 study is that knock-down of VPS34 and Beclin 1 causes instability of USP10 and USP13, which indicates the existence of a regulatory feedback loop [XREF_BIBR]."
25545884
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"The close functional interconnection between the central PI3K-III subunits and the DUBs is demonstrated by the interesting observation that knock-down of VPS34 and Beclin 1 causes instability of USP10 and USP13, which strongly indicates the existence of a regulatory feedback loop [XREF_BIBR]."
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