IndraLab

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OTUD3 deubiquitinates PTEN. 6 / 7
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"It is worth mentioning that OTUD3 is decreased in breast cancer and suppresses tumorigenesis by deubiquitinating PTEN 70."
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"OTUD3 (OTU region) directly interacts with PTEN (C2 domain), deubiquitinating and stabilizing the PTEN protein to suppress PI3K-AKT signaling ."
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"Our previous results showed that OTUD3 can deubiquitinate and stabilize PTEN."
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"Notably, Zhao et al (90) discovered that in thyroid carcinoma, OTUD3 deubiquitinates PTEN, thereby increasing PTEN protein stability and inhibiting the activation of PI3K/AKT signaling."
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"PTEN is ubiquitinated by WWP2 and NEDD4 [ 49 , 50 ] and is deubiquitinated by USP13 and OTUD3 [ 19 , 20 ]."
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"OTUD3 could deubiquitylate and stabilize the tumor suppressor PTEN in breast cancer at the protein level."
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