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USP8 leads to the deubiquitination of BECN1. 6 / 6
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"Additionally, USP8 interacted with p62 and BECN1, which are key regulatory proteins for the induction of autophagy through the TRAF6-dependent ubiquitination (Fig. 8, right) [23,24,48,49], and induced the deubiquitination of p62 and BECN1."
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"Simultaneously, USP8 interacts with BENC1 and p62, and induces the de-ubiquitination of BECN1 and p62, thereby inhibits the induction of autophagy (Fig. 8, right)."
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"USP8 induces deubiquitination of BECN1 and p62 protein related to autophagy induction."
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"Having shown that USP8 induces the deubiquitination of TRAF6, TAB2, and TAK1, and resulted in the attenuation of NF-κB activation induced by TLR4 stimulation, we further investigated whether USP8 induces the deubiquitination of BECN1 and p62."
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"Moreover, Myc-BECN1 was ubiquitinated in the absence of Flag-USP8, whereas significant deubiquitination of Myc-BECN1 could observed in the presence of Flag-USP8 in a dose-dependent manner (Fig. 2B, lane 4–6 vs. lane 3), indicating that USP8 induces the de-ubiquitination of BECN1."
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"Consistently, the wild-type USP8 induced the deubiquitination of BECN1 (Fig. 2C, lane 3 vs 4), whereas the catalytic mutant of USP8 did not (Fig. 2C, lane 5), indicating that the BECN1 deubiquitination by USP8 is dependent on the catalytic activity of USP8."
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