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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PSMD14 inhibits CDKN1A. 3 / 3

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"Furthermore, POH1 silencing resulted in the activation of PARP1, caspase-9, caspase-3, and cytochrome c and upregulation of p53, p21, Bax, Puma, Noxa, and Bim."

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"Although PSMD14 knockdown induced p21 mRNA, its induction was significantly suppressed by SMAD3 knockdown, but not by SMAD2 knockdown through the specific knockdown of either SMAD2 mRNA or SMAD3 mRNA."

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"Similar to a previous report , PSMD14 knockdown strongly induced p21 expression and inhibited RB phosphorylation in melanoma ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...