IndraLab

Statements

PSMD14 inhibits CDKN1A. 4 / 4
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"Knockdown of PSMD14 could facilitate cell apoptosis by increasing cleaved caspase-3 levels, and could cause G1 arrest and cellular senescence by increasing p21 stability in lung adenocarcinoma cells [39]."
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"Furthermore, POH1 silencing resulted in the activation of PARP1, caspase-9, caspase-3, and cytochrome c and upregulation of p53, p21, Bax, Puma, Noxa, and Bim."
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"Similar to a previous report , PSMD14 knockdown strongly induced p21 expression and inhibited RB phosphorylation in melanoma ."
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"Although PSMD14 knockdown induced p21 mRNA, its induction was significantly suppressed by SMAD3 knockdown, but not by SMAD2 knockdown through the specific knockdown of either SMAD2 mRNA or SMAD3 mRNA."
| PMC