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Natural small molecule product U4-I05 inhibits USP4. 1 / 1

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"A natural small molecule product U4-I05 diminished the stem-like features of CSCs and enhanced their sensitivity to oxaliplatin and 5-fluorouracil by targeting inhibition of its deubiquitinating enzyme activity through binding the catalytic domain of USP4 (311 cysteine site) at nanomolar concentrations, triggering proteasome-mediated degradation of beta-catenin and Twist1."

39856683

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IndraLab

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Natural small molecule product U4-I05 inhibits USP4. 1 / 1

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