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Statements

Carvedilol inhibits KCNH2. 9 / 13
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"Carvedilol inhibited HERG current in a concentration-dependent manner, IC 50 is 0.51 µM ( Kawakami et al., 2006 )."
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"Based on these observations, the changes evoked in the macroscopic currents by the conditioning pulse could be explained by a mode transition from conventional, but not blocked, channels to a compound[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Carvedilol at a concentration of 10 microM blocked HERG potassium tail currents by 47%."
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"Thus, it is possible that carvedilol blocks the cardiac repolarizing K + currents including HERG, thereby prolonging action potential duration and causing proarrhythmic effects."
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"This is the first study demonstrating that carvedilol blocks HERG potassium channels."
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"Carvedilol (nonselective), propranolol (nonselective) and ICI 118551 (beta (2)-selective) inhibited HERG current in a concentration dependent manner (IC (50) 0.51, 3.9 and 9.2 microM, respectively)."
16314852
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"Carvedilol inhibited HERG current in a concentration-dependent manner with an IC 50 of 0.51 μM ( Kawakami et al., 2006 )."
17118405
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"Antiarrhythmic drug carvedilol inhibits HERG potassium channels."
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"Antiarrhythmic drug carvedilol inhibits HERG potassium channels."
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