IndraLab

Statements

Carvedilol inhibits KCNH2. 13 / 13
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drugbank
No evidence text available
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No evidence text available
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"Carvedilol inhibited HERG current in a concentration-dependent manner, IC 50 is 0.51 µM ( Kawakami et al., 2006 )."
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"Carvedilol at a concentration of 10 microM blocked HERG potassium tail currents by 47%."
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"Carvedilol inhibited HERG current in a concentration-dependent manner with an IC 50 of 0.51 μM ( Kawakami et al., 2006 )."
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"Thus, it is possible that carvedilol blocks the cardiac repolarizing K + currents including HERG, thereby prolonging action potential duration and causing proarrhythmic effects."
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"This is the first study demonstrating that carvedilol blocks HERG potassium channels."
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"Based on these observations, the changes evoked in the macroscopic currents by the conditioning pulse could be explained by a mode transition from conventional, but not blocked, channels to a compound[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Carvedilol (nonselective), propranolol (nonselective) and ICI 118551 (beta (2)-selective) inhibited HERG current in a concentration dependent manner (IC (50) 0.51, 3.9 and 9.2 microM, respectively)."
16314852
ctd
No evidence text available
16314852
ctd
No evidence text available
11164846
reach
"Antiarrhythmic drug carvedilol inhibits HERG potassium channels."
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"Antiarrhythmic drug carvedilol inhibits HERG potassium channels."
11164846