IndraLab

Statements

X activates USP37. 6 / 6
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"Many recent studies have highlighted the significant role of E3 ubiquitin ligases, deubiquitinases or substrate translocation between cell compartments, leading to substrate stability motivated us to explore the effect of HBx driven exodus of USP37 from the nucleus vis-a-vis its intracellular stability."
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"Conversely, HBx rescued USP37 from CDH1 mediated down-regulation similar to CDC6 but not the other CDH1 substrate, Geminin XREF_BIBR (XREF_FIG)."
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"HBx of HBV could upregulate USP37 transcripts in both hepatic and non-hepatic cells and also prevents USP37 from proteasomal degradation."
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"Thus, we wondered if the effect of DUB inhibitor on SIRT7 protein levels observed in presence of HBx was dependent upon HBx mediated up-regulation of USP37."
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"Ironically, Emi1 overexpression did not lead to USP37 accumulation thereby mitigating the possible role of Emi1 in HBx mediated USP37 stabilization."
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"The HBx dependent up-regulation of USP37 could be seen even in non hepatic cells such as HEK293T and U2OS."
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