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TMEM79 binds USP8 and FZD. 2 / 2

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"These data together suggest that the assembly of the FZD-USP8-TMEM79 complex, in which USP8 action on FZD is inhibited specifically, probably is multivalent in nature and involves additional proteins yet to be identified."

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sparser

"Mechanistically, TMEM79 forms a complex with FZD and USP8 and inhibits USP8 deubiquitination of FZD during biogenesis, thereby promoting trafficking of ubiquitinated FZD from ER to the lysosome for destruction ( xref )."

32924931

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IndraLab

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TMEM79 binds USP8 and FZD. 2 / 2

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