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FZD binds USP8 and TMEM79. 2 / 2

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"Mechanistically, TMEM79 forms a complex with FZD and USP8 and inhibits USP8 deubiquitination of FZD during biogenesis, thereby promoting trafficking of ubiquitinated FZD from ER to the lysosome for destruction ( xref )."

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sparser

"These data together suggest that the assembly of the FZD-USP8-TMEM79 complex, in which USP8 action on FZD is inhibited specifically, probably is multivalent in nature and involves additional proteins yet to be identified."

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IndraLab

Statements

FZD binds USP8 and TMEM79. 2 / 2

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