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CD44 binds CD74 and MIF. 28 / 28
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"It was previously shown that in macrophages, MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway."
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"Interestingly, the interaction between MIF and the complex CD74-CD44 is a top-ranked LR pair in factor 9(Figure 4b), which is consistent with ubiquitous expression of MIF across tissues and its protective role in normal conditions35,53 ."
| DOI
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"Our findings indicate that the tyrosine kinase Lyn is activated when MIF binds to its receptor CD74 and its coreceptor CD44 and, in turn, down-regulates the RANKL-mediated signaling cascade by suppressing NF-ATc1 protein expression through down-regulation of AP-1 and calcium signaling components."
24891319
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"In the current study we demonstrate for the first time that upon binding, the MIF, CD74, and CD44 complex activates the phosphorylation of Lyn during osteoclastogenesis."
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"Also, it was shown that the formation of a molecular complex between MIF, CD74 and CD44 in prostate carcinoma cells lines (DU-145) could mediate signal transduction including (gene regulation, apoptosis, and cell proliferation) in prostate cancer [ xref ]."
31949511
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"Therefore, the CD74, MIF, and CD44 complex initiates a pro survival signal leading to the increase of proliferation and inhibition of apoptosis."
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"It has been reported that MIF mediates many of its inflammatory properties by interacting with the CD74-CD44 MIF receptor complex ( xref )."
22972922
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"The MIF, CD74, and CD44 complex is believed to regulate the signaling of leukocyte migration to sites of inflammation."
23044992
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"It was previously shown that in macrophages, MIF binds to a CD74-CD44 complex."
22454509
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"We developed a tentative model of MIF- CD44- CD74 interaction."
15248897
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"In addition, MIF also binds to the receptor CD44 and the co-receptor CD74."
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"6) In their previous paper (Gore Y et al, J Biol Chem, 2008), it shows that MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway."
33661886
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"We recently documented that MIF associates with CD74 and CD44 in an urothelial cancer cell line [ xref ] and in an in vivo model of bladder inflammation [ xref ] suggesting that the effects of MIF on the bladder are mediated by interaction with both CD74 and CD44."
16000172
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"Therefore, our data was in accordance with a model in which CD74 forms a signaling complex with CD44 to mediate the MIF functions."
26087187
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"MIF binds to the CD74-CD44 complex and induces a signalling cascade that leads to activation of downstream signalling molecules, cellular proliferation, and inhibition of apoptosis by activating the Akt pathway through the upstream proteins Src and PI3K kinase [ xref , xref ]."
20939898
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"Several groups have studied the association of CD74 with MIF and CD44 in cancers since it was reported that CD74 and CD44 are involved in signalling with MIF [ xref ], [ xref ], [ xref ]."
31949511
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"The interaction of MIF with the CD74-CD44 complex leads to the activation of the Src kinase, with consequent phosphorylation of the ½ kinase (ERK1/2) and mitogen-activated protein kinase (MAPK/ERK) [ xref ]."
32344747
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"ILF immunoprecipitation followed by Western blot analysis was performed to identify an association of MIF with CD74 and/or CD44."
15643275
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"Based upon recent experiments by other groups [ xref ], the interaction of MIF with CD74 and CD44 are key to MIF signal transduction."
15248897
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"Hence, it appears that a MIF, CD74, and CD44 complex associates with Lyn after MIF treatment of BMMs."
24891319
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"Immunoprecipitation assays were performed to ascertain whether MIF interacts with CD74 or CD44 in HT-1376 cells."
15248897
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"It has been suggested that the CD74, MIF, and CD44 complex initiates a pro survival signal leading to reduced apoptosis and increased cell proliferation [XREF_BIBR, XREF_BIBR]."
29190904
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"Given the demonstrated binding of MIF to the CD74 and CD44 complex, an interference with the perception of contact inhibition signals by CD44 seems intriguing."
20038293
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"Interestingly, both MIF, CD74, and CD44 have been associated with tumor progression and metastasis ( xref – xref )."
22140262
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"We concluded that the interactions of CD74 with MIF and CD74 with CD44 could be a potential tumour marker for breast cancer cells."
31949511
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"Finally this study ascertains whether MIF associates with CD74 or CD44 in bladder cancer cells."
15248897
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"The interaction of MIF with CD74 and CD44 has been reported, suggesting that MIF in association with CD74 and CD44, as a complex, plays a significant role in bladder cancer cell proliferation [ xref ]."
31949511
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"To enable interaction with CD44, CD74 is modified by the addition of chondroitin sulfate, permitting formation of a molecular complex between MIF, CD74 and CD44 [ xref , xref ]."
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