IndraLab

Statements

UCHL3 activates ossification. 6 / 6
| 6
reach
"MS-BMDM-derived exosomal UCHL3 promotes BMSCs osteogenesis by targeting SMAD1."
36915132
reach
"We next explored the mechanism by which MS-BMDM-derived exosomal UCHL3 modulates BMSCs osteogenesis."
36915132
reach
"Thus, we hypothesized that MS-BMDM-derived exosomal UCHL3 could mediate BMSC osteogenesis through the regulation of SMAD1."
36915132
reach
"Moreover, although we found that MS-BMDM-derived exosomal UCHL3 promotes BMSCs osteogenesis by targeting SMAD1, additional questions, such as binding sites, still require clarification."
36915132
reach
"The ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) in cell-derived exosomes induced by mechanical stimulation promoted osteogenesis in MSCs, thereby facilitating alveolar bone remodeling during orthodontic tooth movement [77]."
37842582
reach
"This study suggests that mechanical force-induced macrophage-derived exosomal UCHL3 promotes BMSCs osteogenesis by targeting SMAD1, thereby promoting alveolar bone formation during OTM."
36915132