IndraLab

Statements

UCHL1 activates HMBS. 3 / 3
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"Mutants of alpha-synuclein, Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) and parkin support the involvement of UPS dysfunction in PD [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29168786
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"UCH-L1 alters the polyubiquitin chain and increases the availability of free monomeric ubiquitin to the UPS, thus increasing proteasome-dependent proteolysis (61)."
34674795
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"We also found that overexpression of UCHL1 increased the UPS related proteins UBE1, PSMA7, ubiquitinated proteins, and monoubiquitin, and proteasomal activity."
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