IndraLab

Statements


| 4

sparser
"However, the estimated charge of the Bap1 protein monomer is −12.9 at pH 7.0 (), providing a possible explanation for the binding of the LL-37 peptide to the negatively charged target protein, the Bap1 protein, by an electrostatic interaction."

sparser
"The mechanism(s) of interaction between the LL-37 and the Bap1 protein is under investigation in our laboratory."

sparser
"Following LL-37 binding by Bap1, the concentration of free LL-37 is reduced to sub-lethal concentrations, leading to the apparent resistance and survival of V. cholerae ."

sparser
"We suggest that due to PmB treatment of the bacterial strain, the OmpT LDV residues become exposed during biogenesis on the surface of the OMVs, allowing for binding of the Bap1 protein and thereby promoting LL-37 binding to Bap1."