IndraLab

Statements

USP22 inhibits MYC. 3 / 3
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"Noticeably, overexpression of Usp22 reduced the survival time of the c‐Myc/NRasGV12 mouse model of HCC (Figure 1B)."
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"Consistently, overexpression of USP22 stimulates while downregulation of USP22 suppresses breast cancer cell growth, migration and tumorigenesis in a MYC dependent manner.113 USP13."
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"Because the Myc protein controls the expression of thousands of other genes, the depletion of cellular USP22 can inhibit Myc function, inhibiting the invasive growth of cancer cells."
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