IndraLab

Statements

USP29 activates glycolytic process. 4 / 4
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"In neuroblastoma, we previously revealed that USP29 promotes glycolysis and glutamine catabolism in normoxia and/or hypoxia."
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"USP29 has also been shown to promote neuroblastoma progression by upregulating glycolysis and glutamine catabolism (Kang et al., 2023)."
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"USP29 was reported to promote tumor cell glycolysis in normoxia or hypoxia by stabilizing HIF1α, and thus, we proposed that USP29 may also regulate de novo nucleotide synthesis under hypoxia.To assess this hypothesis, we depleted endogenous USP29 in SK-N-BE2 cells and then analyzed nucleotide synthesis in cells cultured under hypoxic conditions (1% O ) using C glucose as a tracer."
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"Depletion of USP29 significantly reduces glycolysis and lactate production."
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