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Mutated PRPF8 inhibits U1/5′ss. 1 / 1
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reach
"The fact that the U4-cs1 mutation, which blocks splicing at low temperature by hyperstabilizing the U4/U6 duplex [71] , becomes synthetically lethal in combination with either brr2 - 1 or prp28 - 1 mu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"