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EIF3F increases the amount of PHGDH. 6 / 6
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"Collectively, these results validated the oncogenic role of eIF3f and that eIF3f promoted CRC progression via SGOC pathway reprogramming by regulating PHGDH expression.2.6 Wnt Signaling Transcriptionally Upregulates the Expression of eIF3f."
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"Additionally, Wnt signals transcriptionally activate the expression of eIF3f, which also exerts its deubiquitinating activity toward MYC, thereby increasing MYC-mediated PHGDH transcription."
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"21 We further checked the expression of PHGDH and CAD in eIF3f KD CRC cells and the immunoblotting results showed that knockdown of eIF3f significantly reduced the expression of PHGDH, while exerted little effect on CAD (Figure S2C, Supporting Information)."
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"Indeed, eIF3f KD leads to reduction of steady‐state expression of PHGDH (Figure 2D)."
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"In addition, eIF3f KD accelerates PHGDH protein turnover (Figure 2F), and leads to increased poly‐ubiquitination level of PHGDH (Figure 2G), while ectopic‐expression of eIF3f leads to increased steady‐state expression of PHGDH (Figure 2H) and reduced poly‐ubiquitination level of PHGDH in a dose‐dependent manner (Figure 2I)."
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"The data in this study suggest that eIF3f positively regulated PHGDH expression, thus influencing the SGOC pathway."
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