IndraLab

Statements

USP37 inhibits BRCA1. 5 / 5
| 5
reach
"USP26 and USP37 limit the ubiquitin-dependent sequestration of BRCA1 and facilitate BRCA1-PALB2-BRCA2-RAD51 association at damaged chromatin to promote HR repair [77]."
33797206
reach
"USP26 and USP37 have additionally been shown to impair accumulation of RAP80 and BRCA1 [154]."
32708614
reach
"We reasoned that USP26 and USP37 may antagonize the RAP80 dependent sequestration of BRCA1 by removing RNF8 and RNF168 mediated ubiquitylation and thereby promote HR."
26101254
reach
"In agreement with this hypothesis, we found that USP26 or USP37 depletion inhibits the efficient association of BRCA1 with PALB2, a unique subunit of the BRCC complex."
26101254
reach
"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."
26101254