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EGF sumoylates OTUB2. 11 / 11
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"Poly-SUMOylated OTUB2, which was induced by Epidermal growth factor (EGF) and oncogenic KRAS, was shown to bind and activate YAP/TAZ promoting tumor metastasis [68]."
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"Interestingly, the SUMOylation of OTUB2 is induced by EGF and KRAS [ xref ]."
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"Therefore, our observations suggest that EGF and RAS activation might be able to regulate YAP/TAZ through SUMOylating OTUB2."
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"Interestingly, the SUMOylation of OTUB2 is induced by EGF and KRAS [78]."
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"Furthermore, OTUB2 sumoylation is stimulated by EGF and oncogenic KRAS, which is essential for EGF and KRAS to stabilize Yap/Taz ( xref )."
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"Thus, these clinical data support our model that EGF signaling or RAS activation stimulates OTUB2 SUMOylation and thereby stabilizes YAP/TAZ, which enhances cancer stemness and metastasis ( Figure 7 K[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, we found that EGF, which can activate RAS, also promotes OTUB2 SUMOylation."
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"Moreover, OTUB2 poly-SUMOylation was stimulated by epidermal growth factor (EGF) and oncogenic KRAS mutation."
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"Importantly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ."
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"SUMOylation of OTUB2 by EGF and KRAS stabilizes YAP in the cytosol through deubiquitination, further regulating YAP activation."
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"Moreover, OTUB2 poly-SUMOylation was stimulated by epidermal growth factor (EGF) and oncogenic KRAS mutation."
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