IndraLab

Statements

MiRP1 activates KCNQ1. 6 / 6
| 6
reach
"MiRP1 does not modulate KvLQT1."
10962015
reach
"Our chimera experiments indicate that MiRP1 can not modulate KvLQT1 due to a difference in the transmembrane domain."
10962015
reach
"Based on our previous results that indicate the MinK COOH terminus can modulate KvLQT1 only when an interaction between KvLQT1 and the MinK transmembrane domain occurs, we conclude that MiRP1 does not modulate KvLQT1; in part because of differences in the transmembrane domain that mediate KvLQT1 association."
10962015
reach
"In the same study, CHO cell expression experiments showed that MinK prevented modulation of KCNQ1 by MiRP1, but that MiRPs 2-4 could override effects of MinK on KCNQ1-thus KCNQ1 may be modulated by multiple MiRPs in human heart depending on sub-tissue or even subcellular distribution and other temporal or regulatory factors."
19219384
reach
"The recorded currents exhibit a phenotype identical to that of KvLQT1 alone (XREF_FIG C, left; XREF_TABLE), indicating that MiRP1 and Cterm-MinK either does not associate with and modulate KvLQT1 or that it is not expressed at the cell surface."
10962015
reach
"The results from this analysis indicate that MiRP1 can not modulate KvLQT1 due to differences within the transmembrane domain."
10962015