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Pyrithione inhibits USP14. 2 / 2
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"And only recently we have definitely confirmed that nickel pyrithione (NiPT) inhibits the 19S proteasome-associated deubiquitinases (DUBs) USP14 and UCHL5, but not the 20S proteasome peptidases, and the inhibition of proteasome-associated DUBs induces NiPT-mediated cytotoxicity, revealing a novel mechanism for the anti-cancer effects of nickel-containing compounds [ xref ]."
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"In a recent study, platinum pyrithione (PtPT) was detected to inhibit USP14 activity and have selective cytotoxicity to multiple cancer cells without damaging DNA [ 84 ]."
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