IndraLab

Statements

Dofetilide activates KCNH2. 8 / 8
| 8
reach
"Raising the extracellular potassium to 10 mmol/l, HERG block by azimilide, dofetilide, quinidine and sotalol was significantly decreased, while the block by amiodarone was unchanged."
16960444
reach
"Dofetilide block involves interactions with open and inactivated states of HERG channels."
11907818
reach
"Dofetilide, bepridil, and cisapride are high or intermediate-proarrhythmic-risk drug that prolongs the QT by blocking hERG."
31551815
reach
"Indeed, the pure hERG channel blocker, dofetilide, was shown to increase both QTc (heart rate-corrected QT) and J-T peak c (heart rate-corrected J-T peak ) intervals, while the strong L-type Ca 2+ and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35640715
reach
"Additional application of dofetilide (500 nmol/L) led to complete suppression of I KCNH2."
19959132
reach
"Chronic administration of the I -blocker dofetilide that prolongs repolarization in larger animals and human subjects by blocking HERG channels on the other hand, lengthen repolarization in mice—at least partly—by increasing I (via phosphoinositide 3-kinase pathway) (Yang et al., 2014)."
32581808
reach
"Another approach to (therapeutically) influence repolarization reserve was introduced in a dofetilide-induced LQT2 rabbit model, in which I Ks current densities were enhanced after immunization with a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27210307
reach
"Dofetilide corrected pentamidine induced hERG, but not K (IR) 2.1 trafficking defects."
23586323