IndraLab

Statements

Dofetilide activates KCNH2. 6 / 6
| 6
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"Additional application of dofetilide (500 nmol/L) led to complete suppression of I KCNH2."
19959132
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"Dofetilide corrected pentamidine induced hERG, but not K (IR) 2.1 trafficking defects."
23586323
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"Dofetilide block involves interactions with open and inactivated states of HERG channels."
11907818
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"Dofetilide, bepridil, and cisapride are high or intermediate-proarrhythmic-risk drug that prolongs the QT by blocking hERG."
31551815
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"Raising the extracellular potassium to 10 mmol/l, HERG block by azimilide, dofetilide, quinidine and sotalol was significantly decreased, while the block by amiodarone was unchanged."
16960444
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"Chronic administration of the I -blocker dofetilide that prolongs repolarization in larger animals and human subjects by blocking HERG channels on the other hand, lengthen repolarization in mice—at least partly—by increasing I (via phosphoinositide 3-kinase pathway) (Yang et al., 2014)."
32581808