IndraLab

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KCNH2 activates HFHR. 2 / 2
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"Likewise, several hERG blocking drugs (e.g. dofetilide, thioridazine) known for their association with torsades de pointes in humans have been demonstrated to increase HFHR oscillations in animal studies (Champeroux et al., 2015) which in turn increased the beat-to-beat ventricular repolarisation variability, a situation that favours occurrence of torsades de pointes (Champeroux et al., 2016)."
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"Several hERG blocking drugs known for their propensity to trigger Torsades de Pointes (TdP) were reported to induce a sympatho-vagal coactivation and to enhance High Frequency heart rate (HFHR) and QT oscillations (HFQT) from telemetric data."
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