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Glucose increases the amount of UCHL1. 9 / 9
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"Overall, these results indicated that HG upregulated the expression of UCH-L1 in podocytes at both the mRNA and protein levels."
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"Consistent with this, in differentiated C2C12 myotubes, UCHL1 level was also downregulated by glucose starvation (Figure 1D)."
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"High Glucose Increased the Expression of UCH-L1 in Podocytes in Vitro."
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"In this study, results demonstrated that HG upregulated the expression of UCH-L1 in murine podocytes, which might be mediated by the Wnt and beta-catenin signaling pathway."
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"On the premise that HG increased the expression of UCH-L1, we continued to investigate the influence of UCH-L1 overexpression on podocyte morphology and cell migration."
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"They also proved that the Wnt and beta-catenin signal pathway is promptly activated in podocyte, coinciding with overexpression of UCH-L1 induced by high glucose meanwhile [XREF_BIBR]."
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"Elevated glucose levels trigger the overexpression of UCHL1 in podocytes, which in turn promotes the deubiquitination of RIPK1 and RIPK3, which results in necroptosis of podocytes, causing podocyte depletion95."
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"These results indicated that HG induced the activation of RIPK1/RIPK3 pathway not only caused cell apoptosis and necroptosis but also increased the expression of UCHL1; the latter further enhanced the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, we observed that UCHL1 protein levels in skeletal muscle and C2C12 myotubes were downregulated by fasting or glucose starvation respectively."
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