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OTUB1 increases the amount of RACK1. 6 / 6
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"OTUB1 directly interacted with and increased the expression of oncoprotein RACK1."
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"To determine whether OTUB1 accelerated the development of HCC by modulating RACK1 expression, we loaded siRACK1 into the OTUB1-overexpressed HCC cells and detected the characteristics then."
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"Consistently, OTUB1 overexpression raised the RACK1 protein level in Huh7 cells, whereas MG132 treatment minimized this effect (Fig. 5b)."
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"Rescue assays suggested that OTUB1 promoted the development of OSCC by mediating the RACK1 expression."
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"Combining the results of WB, OTUB1 overexpression increased Ki67 and RACK1 protein levels, while OTUB1 knockdown showed the opposite effects ( p < 0.001) ( Fig. 8 b )."
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"As presented in Fig. 9 f, OTUB1 knockdown decreased the level of RACK1 and increased the level of ubiquitin after suppressing the degradation in the ubiquitin-proteasome mechanism, namely, enhanced th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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