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CACNA1F activates calcium(2+). 8 / 8
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"The gating properties of Cav1.4 channels [11, 53, 64] are perfectly suited to mediate sustained Ca entry needed for continuous release of neurotransmitters at photoreceptor ribbon synapses in the dark [84, 102]."
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"Indeed, heterologously expressed Cav1.4 LTCCs show fast activation and allow Ca influx at membrane potentials negative to − 40 mV."
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"CACNA1F gene encodes a multipass transmembrane protein of 1,977 amino acids which is homologous to L-type calcium channel alpha-1 subunits (the Ca v 1.4 channel) and mediates the influx of calcium ions into the cell [XREF_BIBR, XREF_BIBR]."
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"CACNA1F is located on chromosome Xp11.23, comprising 48 exons, and produces a subunit of the L-type calcium channel Ca 1.4."
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"It comprises 48 exons and codes for the pore‐forming α subunit of the L‐type voltage gated calcium channel (Cav1.4), which localized to rod and cone photoreceptor ribbon synapses and supported Ca influx under relatively depolarized conditions (Abdelkader et al., 2018; Koschak et al., 2021)."
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"For instance, Cacna1f −/− SP thymocytes exhibited more moderate decreases in TCR- or thapsigargin-induced rises in cytosolic-free Ca 2+ relative to WT than what was observed when peripheral naive and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, a specific isoform of CACNA1F (Ca v 1.4) mediates Ca 2+ entry into the photoreceptors and promotes tonic neurotransmitter release ( Strom et al., 1998 )."
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"Variants located in CACNA1C, CACNA1D, CACNA1F and CACNB2 cause gain of function by preventing voltage-dependent inactivation of Ca 1.2, Ca 1.3, Ca 1.4, and Ca β2, leading to excessive influx of Ca ."
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