IndraLab

Statements

PRPF8 activates TP53. 3 / 3
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"Strikingly, silencing of p53 rescues PRPF8 KD-induced apoptosis, indicating that PRPF8 KD triggers hESC apoptosis through activating the p53 pathway."
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"PRPF8 controls alternative splicing of PIRH2 to modulate the p53 pathway and survival of human ESCs."
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"In search for the mechanism by which p53 pathway is activated by PRPF8 KD, we find that PRPF8 KD alters alternative splicing of many genes, including PIRH2 which encodes an E3 ubiquitin ligase of p53."
37357506