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USP13 activates cell cycle. 2 / 2

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"In addition, reconstitution of WT USP13, but not the T196A mutant, fully rescued the foci formation of the BRCA1-A complex, DNA repair and cell cycle checkpoint in USP13 deficient cells and reversed hypersensitivity to cisplatin or olaparib induced by USP13 deficiency (XREF_FIG and XREF_SUPPLEMENTARY)."

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eidos

"This result indicates that USP13 deficiency or inhibition prevents cell cycle arrest in S phase in response to replication stress ."

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IndraLab

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USP13 activates cell cycle. 2 / 2

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