IndraLab

Statements

USP13 activates cell cycle. 7 / 7
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"In addition, reconstitution of WT USP13, but not the T196A mutant, fully rescued the foci formation of the BRCA1-A complex, DNA repair and cell cycle checkpoint in USP13 deficient cells and reversed hypersensitivity to cisplatin or olaparib induced by USP13 deficiency (XREF_FIG and XREF_SUPPLEMENTARY)."
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"USP13 knockdown inhibits cell cycle progression and cell proliferation in GC."
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"USP13 overexpression promotes cell cycle progression and cell proliferation in a DUB enzyme activity dependent manner."
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"Furthermore, USP13 was downregulated in both cancer and healthy tissues.3.11 KDELR3 promotes malignant behaviours and modulates the cell cycle of PC cells."
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"However, the role of USP13 in modulating cell cycle proteins has not been reported yet."
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"This result indicates that USP13 deficiency or inhibition prevents cell cycle arrest in S phase in response to replication stress ."
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"The elevated expression of USP13 promotes the cell cycle progression and cell proliferation by maintaining the stability of cyclin D1."
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