IndraLab

Statements

USP13 inhibits Neoplasms. 7 / 8
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"The reduced volume and weight of tumor nodules caused by USP13 silence was found to be counteracted by ectopic overexpression of METTL3 in 143B cells (Fig. 5a, b)."
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"Our results showed that ZHX2 overexpression could at least partially rescue decreased tumor volume caused by USP13 depletion (Fig. 4 M and N)."
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"For example, USP13 overexpression induces an increase in the expression of the tumor suppressor PTEN in BC cells through deubiquitylation and stabilization of PTEN, thereby inhibiting tumor growth [ 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In conclusion, USP13 either promotes or inhibits the development of different tumors."
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"In addition to its role in breast cancer, USP13 has been demonstrated to suppress tumor development via PTEN in oral squamous cell cancer [36] and bladder cancer [19]."
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"For example, Han et al. (95) reported that inhibiting ubiquitin-specific peptidase 13 (USP13), which upregulates enzymes critical for mitochondrial respiration and glutaminolysis, suppressed tumor progression and sensitized ovarian tumor cells to a PI3K/AKT inhibitor."
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"Targeting USP13 may inhibit tumor growth and provide additional benefits in cooperation with DDR inhibitors and immunotherapy."
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