IndraLab

Statements

Acetylcholine inhibits NLRP3. 3 / 3
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"Interestingly, acetylcholine also inhibits mtDNA release and NLRP3 activation in macrophages, suggesting a novel neurotransmitter–immune cell anti-inflammatory signaling pathway (129)."
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"Amin et al. demonstrated that DMF treatment improved vascular reactivity to KCl and acetylcholine in diabetic rat aorta by suppressing the iNOS and NLRP3 inflammasome and enhancing eNOS expression [42]."
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"Together, these findings reveal a novel neurotransmitter mediated signaling pathway : acetylcholine translocates into the cytoplasm of immune cells during inflammation and inhibits NLRP3 inflammasome activation by preventing mitochondrial DNA release."
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