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Acetylcholine inhibits NLRP3. 2 / 2

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"On the contrary, ACh, main actor in cholinergic anti-inflammatory pathway, inhibits NLRP3 inflammasome by decreasing mtDNA release through binding to mitochondrial α7 nAChR Timp1, that are key drivers of inflammatory signaling [77] ."

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"Together, these findings reveal a novel neurotransmitter mediated signaling pathway : acetylcholine translocates into the cytoplasm of immune cells during inflammation and inhibits NLRP3 inflammasome activation by preventing mitochondrial DNA release."

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Acetylcholine inhibits NLRP3. 2 / 2

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