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Epinastine inhibits KCNH2. 4 / 4
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"The IC 50 concentration of epinastine to block HERG channels was 1000 times higher than that needed to block histamine H 1 receptors.Structural differences between epinastine, astemizole and terfenadi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We further examined the possibility that epinastine may inhibit HERG channels in a use dependent manner."
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"In contrast, 100 microM epinastine inhibited the HERG current by only 11 +/-2.1%."
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No evidence text available
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