IndraLab

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RNF11 inhibits STAMBP. 3 / 3
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"Therefore, RNF11 rescues TGFbeta signalling and causes the degradation of AMSH through a Smurf2 mediated pathway, the implications of which are discussed further below.The TGFbetas belong to a super f[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Concomitantly, RNF11 cooperates with Smurf2 to degrade AMSH, an ubiquitin isopeptidase (a de-ubiquitination enzyme, DUB) that enhances TGFbeta signalling and EGFR-endosomal recycling [3,63]."

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"The potential functions of RNF11 mediated degradation of AMSH in breast cancer are discussed."