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Beta-lapachone inhibits NFKBIA. 3 / 3
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"These results indicate that beta-lapachone blocks NF-kappaB activation by blocking IkappaBalpha degradation.Because the p65 subunit of NF-kappaB also must be translocated to the nucleus for NF-kappaB [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, TNF mediated degradation of IkappaBalpha was abolished in cells treated with beta-lapachone."
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"To determine whether the inhibitory action of beta-lapachone is due to its effect on IkappaBalpha degradation, cells were treated with beta-lapachone for 2 hr and next with TNF for different times."
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