IndraLab

Statements


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"[Cisplatin inhibits proliferation of cervical carcinoma cell line by up-regulating Stat1 expression]."

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"We showed that JWH015 suppressed cisplatin induced STAT1 activation in vitro, which could account for its anti-apoptotic role in UB/OC -1 cell cultures (unpublished data)."

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"Cisplatin increased STAT1 luciferase activity was attenuated by incubation with EGCG (50muM) (XREF_SUPPLEMENTARY) or by STAT1 short interfering RNA (siRNA) (XREF_FIG)."

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"Mean intensity analyses of the images with image J software indicate that the p-STAT3/p-STAT1 ratio is decreased significantly by cisplatin treatment in the OHC and SG, while SVA showed decreased ratio compared to oral PBS control sections."

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"Cisplatin induced p-STAT1 immunoreactivity in OHCs, IHCs, DCs and IPhCs was attenuated by EGCG (XREF_FIG)."

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"While it is possible that the protection of hair cells by EGCG in the present study is due in part to its antioxidant effects, the failure of EGCG to provide additional protection of cisplatin treated hair cells from STAT1-/- mice strongly suggests that EGCG prevents cisplatin induced hair cell death primarily by inhibiting STAT1."