IndraLab

Statements

USP1 binds WDR48 and 3A. 3 / 3
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"Our biochemical reconstitution studies (Fig.  xref and Supplementary Fig.  xref ) revealed that, via its DNA binding activity, RAD51AP1 targets the DNA binding defective USP1-UAF1 3A or USP1-UAF1 11A complex to deubiquitinate FANCD2 on DNA."
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"To ask if UAF1 DNA-binding is relevant for ID2 deubiquitination, we examined the mutant USP1-UAF1 3A and USP1-UAF1 11A complexes (Supplementary Fig.  xref ) in FANCD2 deubiquitination."
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"Since RAD51AP1, which stably associates with UAF1 xref , also possesses DNA binding activity xref , it was of considerable interest to test whether it would restore to USP1-UAF1 3A and USP1-UAF1 11A mutant complexes the ability to deubiquitinate FANCD2 on DNA."
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