IndraLab

Statements

5Z-7-oxozeaenol inhibits MAP3K7. 16 / 16
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"A fungal resorcylic lactone, 5Z-7-oxozeaenol, is known to inhibit the kinase activity of purified TAK1."
27426734
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"As TAK1 inhibition by 5Z-7-oxozeaenol is neuroprotective, the observed decrease seen in vehicle treated mice in pTAK1 in the reperfusion period may reflect an attempt at endogenous neuroprotection."
22683931
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"5Z-7-oxozeaenol selectively inhibits the catalytic activity of TAK1 but has minimal effects on other MAP kinases or JNK."
22683931
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"5Z-7-oxozeaenol, a resorcylic acid lactone derived from fungus, is a powerful inhibitor of TAK1."
29163172
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"For Tak1 inhibitor treatment, the specific Tak1 inhibitor 5Z-7-oxozeaenol (5Z-7-ox; O9890-1 MG; Sigma, St Louis, MO, USA) was administered intraperitoneally to male non transgenic (NTG) and Traf6-TG mice (5mgkg -1) to inhibit Tak1 activation."
27249171
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"Cell culture experiments demonstrated that either siRNA knockdown or 5Z-7-oxozeaenol inhibition of TAK1 significantly attenuated NADPH oxidase activation and superoxide production induced by CD40L and CD40 stimulation."
25050617
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"Together, TAK1 inhibition by 5Z-7-oxozeaenol significantly enhanced the inhibitory effect of Dox and VP-16 on anchorage independent neuroblastoma cell growth."
23700229
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"5Z-7-oxozeaenol and SB203580, which block TAK1 and p38 kinase respectively, abrogated the LTB4 inhibitory effect on L-type calcium channels."
26584289
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"The specific TAK1 inhibitor 5Z-7-oxozeaenol (5Z-7-ox; O9890-1 MG; Sigma) was administered intraperitoneally to NTG and TRAF3-LTG mice (5mgkg -1) in parallel to inhibit TAK1 activation."
26882989
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"This compound did not effectively inhibit the catalytic activities of the MEKK1 or ASK1 MAPKKKs, suggesting that 5Z-7-oxozeaenol is a selective inhibitor of TAK1."
12624112
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"In the heart, unlike our findings in the brain, inhibition of TAK1 by 5Z-7-oxozeaenol led to increased cardiomyocyte death after cardiac ischemia, suggesting that TAK1 has anti-apoptotic effects."
22683931
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"5Z-7-oxozeaenol, a resorcylic lactone of fungal origin, has been reported to selectively inhibit TAK1."
20168333
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"One such compound is 5Z-7-oxozeaenol, which selectively inhibits TAK-1 and has been shown to reduce inflammation and enhance the sensitivity of breast and pancreatic cancer cells to various chemotherapeutic agents, further highlighting the central role that IRAK signaling plays in chemotherapy resistance."
25452754
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"We first tested whether inhibition of TAK1 activity by 5Z-7-oxozeaenol (5Z), an inhibitor of TAK1, was able to block S. Typhimurium induced autophagy and AMPK activation."
29752434
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"In cell culture, 5Z-7-oxozeaenol blocked interleukin-1-induced activation of TAK1, JNK and p38 MAPK, IkappaB kinases, and NF-kappaB, resulting in inhibition of cyclooxgenase-2 production."
12624112
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"Results from ELISA showed that 5Z-7-oxozeaenol effectively decreased the level of p-TAK1 and inflammatory cytokines (IL-1beta and TNF-alpha) in primary alveolar macrophages isolated from silica exposed rats in dose dependent manners (XREF_SUPPLEMENTARY)."
28698801