IndraLab

Statements


PML inhibits USP7. 3 / 3
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"47 In addition, PML negatively regulates the function of HAUSP through DAXX to further modulate PTEN activity in a context specific manner."

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"PML is required to inhibit USP7, thus preventing the deubiquitination of the tumor suppressing phosphatase PTEN."

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"Conversely, PML negatively regulates the DUB HAUSP and USP7, thus opposing PTEN deubiquitination and cytoplasmic translocation."