IndraLab

Statements

PML inhibits USP7. 4 / 4
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"Interestingly, this PTEN relocation doesn’t happen in a specific subset of leukemia stem cells because they have a high level of another protein called PML, which prevents HAUSP from affecting PTEN [44]."
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"47 In addition, PML negatively regulates the function of HAUSP through DAXX to further modulate PTEN activity in a context specific manner."
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"Conversely, PML negatively regulates the DUB HAUSP and USP7, thus opposing PTEN deubiquitination and cytoplasmic translocation."
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"PML is required to inhibit USP7, thus preventing the deubiquitination of the tumor suppressing phosphatase PTEN."
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