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USP12 activates YAP1. 3 / 3
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"We then investigated the effect of USP12 overexpression on YAP protein half-life and found that USP12 overexpression increased YAP protein stability, whereas USP12 enzyme inactivation mutants USP12 did not (Fig. 6G, H)."
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"Taken together, these findings indicate that USP12 can activate HIPPO/YAP signaling, with this effect being dependent on its deubiquitinating enzyme activity."
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"Notably, USP12 depletion was found to inhibit gastric cancer progression via the Hippo/YAP axis, whereas USP12 overexpression exhibited the opposite effect, promoting gastric cancer growth and enhancing YAP activity."
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