IndraLab

Statements

Disulfiram inhibits NLRP3. 13 / 13
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"In this study, we identified disulfiram (DSF), an old marketed drug as a treatment for alcoholism, could effectively inhibit NLRP3 inflammasome activation and suppress pyroptotic cell death."
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"Disulfiram (DSF), by reducing oxidative stress and blocking NLRP3 inflammasome, is an FDA-approved drug to treat chronic alcohol-use disorder."
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"In 2020, Hu et al. published an article supporting the above findings of the disulfiram inhibition of the NLRP3 inflammasome and subsequent inhibition of pyroptosis in vitro [119]."
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"Recently, it has been shown that the aldehyde dehydrogenase inhibitor disulfiram blocks NLRP3 inflammasome activation by suppressing the NLRP3 palmitoylation at cysteine 126 (Cys126)[60]."
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"FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation."
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"Consistent with these results, we found that disulfiram specifically inhibits NLRP3 but not other inflammasomes in macrophages."
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"Disulfiram also seems to inhibit the NLRP3 inflammasome upstream of gasdermin D, resulting in inhibition of release of the same inflammatory cytokines (92)."
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"In this study, we discovered that disulfiram, a safe US Food and Drug Administration (FDA)-approved drug, specifically inhibits the NLRP3 inflammasome but not the NLRC4 or AIM2 inflammasomes."
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"Administration of disulfiram to animals inhibited the NLRP3, but not NLRC4, inflammasome in vivo."
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"Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation."
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"For example, the FDA-approved drug disulfiram inhibits NLRP3 palmitoylation, preventing its localization at the TGN ."
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"Studies have substantiated that NAFLD mice fed disulfiram inactivated NLRP3, thereby reducing mitochondrial ROS production [27] ."
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"Furthermore, disulfiram has been shown to suppress the activation of the NLRP3 inflammasome, which is involved in neuroinflammation [62]."
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