IndraLab

Statements

Mgt inhibits KCNA3. 9 / 9
| 9
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"Subsequent Kv1.3 inhibition by MgTX led to a significant decrease in tumor volume by increasing p21 levels and decreasing Cdk4 and cyclin D3 [ xref , xref ]."
38730738
sparser
"MgTx was considered a selective inhibitor of the Kv1.3 channels but it was demonstrated that MgTx inhibits Kv1.2 and Kv1.3 channels with low picomolar affinities (Kd = 11.7 pM for Kv1.3 and Kd = 6.4 pM for Kv1.2) [ xref ]."
32429050
sparser
"To identify the genes related to the MgTX-induced Kv1.3 inhibition, we studied the transcriptome profile of RAW264.7 cell lines following treatment with MgTX (10 nM)."
32025214
sparser
"However, both Kv1.2 and Kv1.3 were inhibited by MgTx at this concentration ( xref , Mann-Whitney U, non-parametric paired t -test, p = 0.0013 for Kv1.2, n = 6-7; p = 0.0001 for Kv1.3, n = 16-18)."
27861889
sparser
"Inhibition of Kv1.3 by MgTX resulted in a significantly greater fall in blood glucose in both db/db and ob/ob mice receiving insulin compared with those given PBS and insulin."
15948674
sparser
"MgTX inhibits ion channel subtype Kv1.3 [ xref ]."
38730738
sparser
"When unbound MgTx inhibits Kv1.3, a strong shift in activation voltage and a clear loss of voltage dependence is observed in comparison to control solution."
27861889
sparser
"Inhibition of mouse Kv1.3 and Kv1.1 by recombinant MgTx and AgTx2."
23300835
sparser
"In these studies, it was noted that Kv1.3 inhibition by either correolide or MgTX resulted in a significant reduction in inflammatory cytokines, including IL-2 and TNF-α production."
15948674