IndraLab

Statements

Mgt inhibits KCNA3. 5 / 5
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"To identify the genes related to the MgTX-induced Kv1.3 inhibition, we studied the transcriptome profile of RAW264.7 cell lines following treatment with MgTX (10 nM)."
32025214
sparser
"Inhibition of mouse Kv1.3 and Kv1.1 by recombinant MgTx and AgTx2."
23300835
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"However, both Kv1.2 and Kv1.3 were inhibited by MgTx at this concentration ( xref , Mann-Whitney U, non-parametric paired t -test, p = 0.0013 for Kv1.2, n = 6-7; p = 0.0001 for Kv1.3, n = 16-18)."
27861889
sparser
"When unbound MgTx inhibits Kv1.3, a strong shift in activation voltage and a clear loss of voltage dependence is observed in comparison to control solution."
27861889
sparser
"MgTx was considered a selective inhibitor of the Kv1.3 channels but it was demonstrated that MgTx inhibits Kv1.2 and Kv1.3 channels with low picomolar affinities (Kd = 11.7 pM for Kv1.3 and Kd = 6.4 pM for Kv1.2) [ xref ]."
32429050