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HIF1AN hydroxylates OTUD7B. 2 / 2

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"For instance, hydroxylation of the UBA domain of OTUD7B (Cezanne) by factor inhibiting HIF1 (FIH1) prevents binding to Ub ( Mader et al., 2020 )."

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"Finally, the DUB Cezanne (OTUD7B) is hydroxylated by the asparaginyl β-hydroxylase factor inhibiting HIF1 (FIH1) within a domain similar to the Ub-associated domain, and this modification blocks Ub-binding, although the significance of this event remains unknown (172)."

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HIF1AN hydroxylates OTUD7B. 2 / 2

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