IndraLab

Statements

ATXN3 activates DNA repair. 3 / 3
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"As a DUB, ATXN3 stabilizes the ATR downstream targets Chk1 (Checkpoint Kinase 1) and p53 (tumor protein 53), both of which function to delay cell cycle progression and promote DNA repair."
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"Our studies described in the accompanying manuscript by Chatterjee et al suggest that PNKP is a native ATXN3 interacting protein, and that ATXN3 modulates PNKP activity and DNA repair (Chatterjee et al, Figs."
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"Clearly, loss of ATXN3 can impair multiple DNA repair processes."
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