IndraLab

Statements

PRL phosphorylates STAT5 on tyrosine. 12 / 12
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"Prolactin stimulation of transfected cells induces Stat5 phosphorylation on tyrosine."
7925280
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"We find that PRL stimulated tyrosine phosphorylation of Stat5, induced nuclear protein binding to the GH responsive element of the serine protease inhibitor (Spi) 2.1 promoter, and activated Spi 2.1 gene expression."
8892312
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"Formation of this complex and tyrosine phosphorylation of STAT5 in response to prolactin requires the SH2 domain closer to the C-terminus and the catalytic activity of Shp-2."
20157547
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"The DNA binding activity of Stat5, also known as mammary gland factor, has been shown to require prolactin induced tyrosine phosphorylation of a specific C-terminal tyrosine residue in the Stat5 seque[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9923445
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"PRL induced STAT tyrosine phosphorylation in the human T47D mammary adenocarcinoma line and the rat Nb2 lymphoma line In order to establish which STAT transcription fac tors are used by PRL receptors,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8737372
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"For the mucosal epithelium, the presence of the LF was also observed in patches throughout the oviduct in some of the transgenic animals and further demonstrated by PRL tyrosine phosphorylation of STAT5."
35812077
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"We find that PRL stimulated tyrosine phosphorylation of Stat5, induced nuclear protein binding to the GH responsive element of the serine protease inhibitor (Spi) 2.1 promoter, and activated Spi 2.1 g[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8892312
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"55 PRLRs and maybe some tyrosine phosphorylation of STAT5 in response to acutely elevated PRL was also seen in the smooth muscle of the oviduct."
35812077
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"As shown by a representative Western blot of CD34 + cell lysates, STAT-5 tyrosine phosphorylation was similarly induced by PRL and IL-3."
11495699
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"A single injection of rat PRL to hormone deficient female rats stimulated tyrosine phosphorylation of Stat5, induced nuclear protein binding to the GH responsive element of the Spi 2.1 promoter, and a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8892312
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"Prolactin does not induce tyrosine phosphorylation of its receptor, Jak2, or Stat5 in nondifferentiated breast epithelia cultured on collagen I, and we show that this is due to a vanadate sensitive activity that inhibits the prolactin pathway."
9545277
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"PTP1B overexpression markedly suppressed prolactin induced tyrosine phosphorylation of Stat5."
20952588