IndraLab

Statements


PRL leads to the phosphorylation of STAT5 on tyrosine. 10 / 10
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"Formation of this complex and tyrosine phosphorylation of STAT5 in response to prolactin requires the SH2 domain closer to the C-terminus and the catalytic activity of Shp-2."

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"As shown by a representative Western blot of CD34 + cell lysates, STAT-5 tyrosine phosphorylation was similarly induced by PRL and IL-3."

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"Prolactin does not induce tyrosine phosphorylation of its receptor, Jak2, or Stat5 in nondifferentiated breast epithelia cultured on collagen I, and we show that this is due to a vanadate sensitive activity that inhibits the prolactin pathway."

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"PRL induced STAT tyrosine phosphorylation in the human T47D mammary adenocarcinoma line and the rat Nb2 lymphoma line In order to establish which STAT transcription fac tors are used by PRL receptors,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The DNA binding activity of Stat5, also known as mammary gland factor, has been shown to require prolactin induced tyrosine phosphorylation of a specific C-terminal tyrosine residue in the Stat5 seque[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"A single injection of rat PRL to hormone deficient female rats stimulated tyrosine phosphorylation of Stat5, induced nuclear protein binding to the GH responsive element of the Spi 2.1 promoter, and a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"STAT-5 tyrosine phosphorylation was similarly induced by PRL and IL-3, with an additive effect detected in the presence of both stimuli."

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"We find that PRL stimulated tyrosine phosphorylation of Stat5, induced nuclear protein binding to the GH responsive element of the serine protease inhibitor (Spi) 2.1 promoter, and activated Spi 2.1 g[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Prolactin stimulation of transfected cells induces Stat5 phosphorylation on tyrosine."

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"PTP1B overexpression markedly suppressed prolactin induced tyrosine phosphorylation of Stat5."