IndraLab

Statements

SKP2 leads to the ubiquitination of USP18. 4 / 4
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"We also show that Skp2 promotes UBP43 ubiquitination and degradation, resulting in higher levels of ISG15 conjugates."
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sparser
"Mechanistically, the association of USP18 with free intracellular ISG15 prevents SCF SKP2 -mediated USP18 ubiquitination and subsequently its proteasomal degradation, thereby leading to the prevention of autoinflammation and over-amplification of IFN, which suggests that the long-term stabilization of USP18 by free intracellular ISG15 is essential for the negative feedback regulation of IFN signaling [ xref ]."
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reach
"The skp2 protein, a substrate recognition factor for SCF-E3 ubiquitin ligase complexes, promoted USP18 ubiquitination and degradation [82] ."
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ubibrowser
"E3Net"
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