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P5091 inhibits cell population proliferation. 13 / 13
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"The USP7 selective small-molecule inhibitors P5091 and P22077 inhibited cell proliferation and induced megakaryocytic differentiation in both cell lines and primary cells."
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"P5091 decreases proliferation in harvested tumors, as assessed by BrdU and Ki67 staining (XREF_FIG, and XREF_SUPPLEMENTARY)."
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"P5091 has also been reported to inhibit colorectal tumor growth in an HCT116 xenograft mouse model by suppressing proliferation and inducing apoptosis in CRC cells [221]."
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"Co-treatment with P5091 and melatonin significantly suppressed H1299 cell proliferation (Fig. 6D, E)."
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"Tumor cell proliferation was downregulated by P5091 and anti-PD-1 treatment as evidenced by hematoxylin and eosin stain (H&E) and proliferating cell nuclear antigen (PCNA) immunohistochemistry staining."
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"P5091 inhibited HCT166 proliferation [86] , whereas P22077 downregulated the USP7 targets MDM2, claspin, and Checkpoint kinase 1 (Chk1) and inhibited neuroblastoma growth [75] ."
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"All of these results proved that both P5091 and anti-PD-1 treatment enhanced tumor proliferation inhibition and apoptosis in vivo."
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"Interestingly, both P5091 and P22077 treatment apparently blocked Daoy cell proliferation and metastasis ( Fig. 4 A and B)."
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"Taken together, these results are consistent with the findings shown in the cultured cells, suggesting that P5091 inhibits the Wnt signaling and proliferation of colon cancer cells both in vitro and i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P5091 treatment inhibited BMSCs induced proliferation of MM.1 S (XREF_FIG)."
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"In vitro, P5091 inhibits proliferation of CRC cells and induces apoptosis."
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"The P5091 treatment attenuated the proliferation of the 22Rv1 cells in the absence or presence of DHT."
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"To assess whether Usp7 inhibitors block MB cell proliferation and migration, we treated the cells with P5091 or P22077 at corresponding concentrations as previously described [19,20] ."
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