IndraLab

Statements

USP44 activates FOXP3. 5 / 5
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"Combined USP7 and USP44 knockdown, however, even further enhanced FOXP3 degradation (Fig XREF_FIG D, left panel)."
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"These results suggest that Tregs devoid of USP44 mediated FOXP3 stabilization are ineffective suppressors of anti-tumor immune responses."
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"For example, USP44 and USP7 appeared to promote FOXP3 function in regulating Th17- and Treg-cell differentiation (11, 12)."
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"USP44 promotes FOXP3 stabilization through deubiquitination."
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"Suspecting that USP44 targets FOXP3 for deubiquitination, we again utilized a co-IP approach to test this notion."
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