IndraLab

Statements

USP1 increases the amount of CHEK1. 3 / 3
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"Nonetheless, it is probable that the parallel loss of USP1 and Claspin works synergistically to down-regulate CHK1 protein levels and activity."
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"Co-depletion of USP1, together with the FANCcore complex proteins FANCC or FANCD2, rescued the steady-state level of CHK1."
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"Indeed, simultaneous USP1 knockdown reversed the BRD7 deficiency-induced chemosensitization to CHK1 inhibitors (Fig. 6A), as well as increased protein level of CHK1 (Fig. 6A, lanes 3 versus 2)."
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