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"Moreover, we found that replacing endogenous RNF8 with a catalytically inactive mutant (C403S; denoted as * RING), which impairs RNF8 dependent ubiquitylation and 53BP1 accumulation at DSBs (Mailand etal, 2007), did not impair accrual of ataxin-3 (Fig XREF_FIG F and G)."