IndraLab

Statements

UCHL3 increases the amount of UCHL3. 3 / 3
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"UCHL3 promoter analysis revealed that TEAD4, through which YAP bind to DNA, activated UCHL3 transcription by binding to the promoter of UCHL3."
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"RT-qPCR analysis demonstrated no significant differences in UCHL3, NEDD8 and LC3B expression levels between the NC and si-NC groups (P>0.05; Fig. 4A and B); however, UCHL3 knockdown significantly decreased the expression levels of UCHL3 and NEDD8, and significantly increased LC3B expression in the si-UCHL3 group compared with the NC group (all P<0.001; Fig. 4A and B)."
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"According to Western blot analysis results, protein levels of UCHL3, AhR and PD-L1 were all reduced in response to sh-UCHL3 treatment, while additional LV-AhR restored the protein levels of AhR and PD-L1 but showed on obvious effects on the UCHL3 protein level; consistently, LV-UCHL3 led to up-regulated protein levels of UCHL3, AhR and PD-L1, among which only the up-regulation of AhR and PD-L1 was reversed in response to additional sh-AhR treatment (Fig. 2M)."
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